Cardioprotective potential of oleuropein, hydroxytyrosol, oleocanthal and their combination: Unravelling complementary effects on acute myocardial infarction and metabolic syndrome

• DOI: 10.1016/j.redox.2024.103311
• Publication Date: 2024-08-14T07:02:05Z
• Authors: Andriana Christod...; Panagiota-Efstath...; Lydia Symeonidi; Konstantinos Kato...; Louisa Pechlivani; Theodora Nikou; Aimilia Varela; Christina Chania; Stelios Zerikiotis; Panagiotis Efentakis; Dimitris Vlachodi...; Nikolaos Katsoulas; Anna Agapaki; Costantinos Dimit...; Maria Tsoumani; Nikolaos Kostomit...; Constantinos H. D...; Alexios Leandros ...; Alexandros Tselepis; Maria Halabalaki; Ioulia Tseti; Efstathios K. Ili...; Ignatios Ikonomidis; Ioanna Andreadou
• Keywords: Hydroxytyrosol; Oleuropein

Clinical studies have previously established the role of olive products in cardiovascular disease (CVD) prevention, whilst identification responsible constituents for beneficial effects is still pending. We sought to assess and compare cardioprotective potential oleuropein (OL), hydroxytyrosol (HT), oleocanthal (OC) oleanolic Acid (OA), regarding Ischemia/Reperfusion Injury (IRI) CVD risk factors alleviation. The scope study was design a potent safe combinatorial therapy high-cardiovascular-risk patients on bench-to-bedside approach. evaluated IRI-limiting 6-weeks treatment with OL, HT, OC or OA at nutritional doses, healthy metabolic syndrome (MS)-burdened mice. Three regimens were designed mixture preponderant benefits (OL-HT-OC, Combo 2), including infarct sparing antiglycemic potency, compared isolated compounds, further investigated its anti-atherosclerotic effects. In vivo experiments revealed that combination regimen 2 presented most favorable limiting size hyperglycemia, which selected be clinical setting Chronic Coronary Artery Syndrome (CCAS) patients. Cardiac function, inflammation markers oxidative stress assessed baseline after 4 weeks OL-HT-OC supplement study. found significantly reduced Controls. OL exhibited antihyperglycemic properties attenuated hypercholesterolemia. OL-HT-OA, OL-HT-OC-OA cardioprotective, whereas only mitigated hyperglycemia. cardioprotection attributed apoptosis suppression, enhanced antioxidant upregulation enzymes. Additionally, it atherosclerotic plaque extent vivo. ameliorated cardiac, vascular endothelial function small-scale Conclusively, exerts vivo, remarkable clinically translatable high-risk