Circulating miR-3613-5p but not miR-125b-5p, miR-199a-3p, and miR-451a are biomarkers of endometriosis

• DOI: 10.1016/j.repbio.2023.100796
• Publication Date: 2023-08-21T16:01:40Z
• Authors: Izabela Walasik; Klaudia Klicka; Tomasz M. Grzywa; Iwona Szymusik; Paweł Włodarski; Mirosław Wielgoś; Bronisława Pietrzak; Artur Ludwin
• Keywords: MicroRNAs; ROC Curve; Endometriosis; Humans; Female; Prospective Studies; Biomarkers; 3. Good health

This study aimed to assess the utility of circulating miR-125b-5p, miR-199a-3p, miR-451a, and miR-3613-5p as biomarkers endometriosis.Patients with stage III or IV endometriosis according revised American Society Reproductive Medicine (rASRM) staging classification, well control women, were recruited. We created a prospective conducted on group 48 patients (n = 25 controls, n 24 endometriosis) who had laparoscopic surgery. Blood samples taken plasma miRNA levels measured by quantitative real-time polymerase chain reaction (RT-qPCR) assessed AUC ROC curves.MiR-451a significantly decreased in patients. miR-451a receiver-operating characteristic (ROC) area under curve 0.8283 0.7617. The concentration miR-125b-5p miR-199-3p did not differ between controls. Plasma change BMI, smoking status, fertility problems, menstrual pain VAS scale (p > 0.05).Circulating differed However, discordant previous studies. Therefore, may have better potential biomarker. Circulating miR-199a-3p cannot be used reliable markers endometriosis.