Mitophagy in mammalian follicle development and health

• DOI: 10.1016/j.repbio.2024.100889
• Publication Date: 2024-05-11T02:59:00Z
• Authors: Zhengrong Zhou; Zhipeng Wu; Liufang Zhang; Yue Dai; Genbao Shao; Caifang Ren; Pan Huang

Mitophagy, the cellular process that removes damaged mitochondria, plays a crucial role in maintaining normal cell functions. It is deeply involved in the entire process of follicle development and is associated with various ovarian diseases. This review aims to provide a comprehensive overview of mitophagy regulation, emphasizing its role at different stages of follicular development. Additionally, the study illuminates the relationship between mitophagy and ovarian diseases, including ovary aging (OA), primary ovarian insufficiency (POI), and polycystic ovary syndrome (PCOS). A detailed understanding of mitophagy could reveal valuable insights and novel strategies for managing female ovarian reproductive health.