A case of pulmonary tumor thrombotic microangiopathy following lymphedema on the lower extremities

• DOI: 10.1016/j.rmcr.2022.101631
• Publication Date: 2022-03-15T07:51:22Z
• Authors: Yuri Shiraiwa; Yuri Taniguchi; Mari Hyoudou; Aya Shiba; Masaharu Aga; Kazuhito Miyazaki; Yusuke Hamakawa; Yuki Misumi; Yoko Agemi; Tsuneo Shimokawa; Chie Hasegawa; Hiroyuki Hayashi; Hiroaki Okamoto
• Keywords: Thrombotic microangiopathy; Microangiopathy

Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare manifestation of malignancy. The antemortem diagnosis difficult, since patients present with rapidly progressive symptoms. We recently observed case PTTM following lymphedema the lower extremities. did not reach diagnosis, even after performing BAL and TBLB. patient manifested pulmonary hypertension died on 9th day admission. Autopsy revealed embolism in arterioles accompanied by fibrocellular epithelial cell proliferation, but primary organ was identified. To our knowledge, this first reported lymphedema.