Long-term exposure to genistein inhibits the proliferation of gallbladder cancer by downregulating the MCM complex

• DOI: 10.1016/j.scib.2022.01.011
• Publication Date: 2022-01-17T06:56:38Z
• Authors: Yajun Geng; Shili Chen; Yang Yang; Huijie Miao; Xuechuan Li; Guoqiang Li; Jian Ma; Tong Zhang; Tai Ren; Yongsheng Li; Lin Li; Liguo Liu; Jiahua Yang; Ziyi Wang; Lu Zou; Ke Liu; Yang Li; Siyuan Yan; Xuya Cui; Xuheng Sun; Bo Yang; Lingxiao Zhang; Xusheng Han; Chuanlei Wang; Bo Chen; Xueliang Yue; Wei Liang; Jianjun Ren; Jianguang Jia; Jianfeng Gu; Zhizhen Li; Tiansuo Zhao; Peng Wang; Dong Wei; Shimei Qiu; Dongxi Xiang; Xinsen Xu; Wei Chen; Min He; Linhua Yang; Hui Wang; Tao Chen; Rong Hua; Xu'an Wang; Xiangsong Wu; Wei Gong; Guangyi Wang; Maolan Li; Wei Zhang; Rong Shao; Wenguang Wu; Yingbin Liu
• Keywords: Gallbladder Cancer

Soy isoflavones are natural tyrosine kinase inhibitors closely associated with decreased morbidity and mortality of various tumors. The activation kinases such as ERBB2 is the mechanism by which cholecystitis transforms into gallbladder cancer (GBC), therefore, it important to investigate relationship between long-term exposure soy occurrence progression GBC. This case-control study (n = 85 pairs) found that high level plasma isoflavone-genistein (GEN) was a lower risk (≥326.00 ng/mL compared ≤19.30 ng/mL, crude odds ratio 0.15, 95% CI 0.04-0.59; P for trend 0.016), GEN negatively correlated Ki67 expression in GBC tissue 85). Consistent these results, proliferation cells inhibited models vitro vivo. reduced activity impaired function PTK6-AKT-GSK3β axis, leading downregulation MCM complex cells. In summary, products intake might play certain role preventing even inhibiting