Cardiac dysfunction affects eye development and vision by reducing supply of lipids in fish

• DOI: 10.1016/j.scitotenv.2021.149460
• Publication Date: 2021-08-05T11:09:09Z
• Authors: Elin Sørhus; Sonnich Meier; Carey E. Donald; Tomasz Furmanek; Rolf B. Edvardsen; Kai K. Lie
• Keywords: Embryo, Nonmammalian; Heart Diseases; Larva; Fishes; Animals; Petroleum Pollution; Lipids; Water Pollutants, Chemical

Developing organisms are especially vulnerable to environmental stressors. Crude oil exposure in early life stages of fish result multiple functional and developmental defects, including cardiac dysfunction abnormal smaller eyes. Phenanthrene (Phe) has a reversible impact on function, under Phe reduces contractility. Exposure known L-type channel blocker, nicardipine hydrochloride (Nic) also disrupts function creates eye deformities. We aimed investigate whether was the major underlying mechanism crude oil-, Phe- Nic-induced malformations. exposed Atlantic haddock (Melanogrammus aeglefinus) embryos Nic (Oil) late embryos/early larvae exposure. All three exposures resulted abnormalities lead severe, eye, jaw spinal deformities at larval stages. At 3 days post hatching, from corresponding controls were dissected. Eyes, trunk, head yolk sac subjected lipid profiling, eyes transcriptomic profiling. Among most enriched pathways transcriptomes fatty acid metabolism, calcium signaling phototransduction. Changes profiles transcriptome suggested that dysfunctional our due both disruption insufficient supply essential acids other nutrients form yolk.