Oxidative potential induced by metal-organic interaction from PM2.5 in simulated biological fluids

• DOI: 10.1016/j.scitotenv.2022.157768
• Publication Date: 2022-08-03T00:55:50Z
• Authors: Na Wu; Yan Lyu; Bingqing Lu; Dongmei Cai; Xue Meng; Xiang Li
• Keywords: Oxygen; Air Pollutants; Oxidative Stress; Coordination Complexes; Metals; Nitrogen; Humans; Particulate Matter; 01 natural sciences; Environmental Monitoring; 0105 earth and related environmental sciences

The oxidative potential (OP) of fine particulate matter (PM2.5) has recently been proposed as a metric that may prove more indicative of human health effects than the routinely measured PM2.5 concentration. Observations of exposure to PM2.5 show most OP are originated from the contribution of transition metals and organics, but the pertinent coupling mechanisms are unclear. Here, we report laboratory observations in four simulated biological fluids (i.e., simulated saliva, surrogate lung fluid, artificial lysosomal fluid, and synthetic serum) that reveal OP of PM2.5 are significantly induced by prevalent metal complexes formed with nitrogen- and oxygen-containing compounds in low acid environments. Analyses of mass spectra and interaction factors indicate that organic-metal mixture effect in PM2.5, leading to synergistic, additive to antagonistic effects, which may serve as the dominant mechanism for this OP formation. A metal-organic mixtures origin for OP could explain why PM2.5 emission controls should emphasize the reduction of key toxic components, rather than just PM2.5 mass concentration control. SYNOPSIS: This study has investigated the oxidative potential of inhaled atmospheric particulate matter (PM) in four simulated biological fluids, which highlight the importance of metal-organic complexes to the formation of oxidative potential (OP).