Bioaccumulation of pharmaceuticals and stimulants in macrobenthic food web in the European Arctic as determined using stable isotope approach

• DOI: 10.1016/j.scitotenv.2023.168557
• Publication Date: 2023-11-17T20:53:49Z
• Authors: Adam Sokołowski; Marlena Mordec; Magda Caban; Ida Beathe Øverjo...; Ewa Wielogórska; Maria Włodarska-K...; Piotr Balazy; Maciej Chełchowski; Gilles Lepoint
• Keywords: Biomagnification; Isotope Analysis

Although pharmaceuticals are increasingly detected in abiotic matrices the Arctic, accumulation of drugs resident biota and trophic transfer have not been yet examined. This study investigated behaviour several rocky-bottom, macrobenthic food web coastal zone Isfjorden (western Spitsbergen) using stable isotope analyses (SIA) coupled with liquid chromatography-mass spectrometry (LC-MS/MS). Across 16 macroalgal invertebrate species highest average concentration was measured for ciprofloxacin (CIP) (on 60.3 ng g-1 dw) followed by paracetamol (PCT) (51.3 nicotine (NIC) (37.8 dw). The biomagnification potential assessed six target compounds 13 analytes that were quantified a frequency > 50 % biological samples. magnification factor (TMF) ranged between 0.3 2.8, significant NIC CIP. TMF < 1.0 (0.3; confidence interval, CI 0.1-0.5) indicated compound does accumulate position. dilution pharmaceutical residues may result from limited intake dietary route, poor assimilation efficiency high biotransformation rates benthic invertebrates. CIP (2.8, 1.2-6.4) suggests magnification, phenomenon observed previously antibiotics freshwater webs. Trophic therefore plays role controlling Arctic communities should be considered environmental risk assessment. Biomagnification diclofenac (DIC; 0.9, 0.5-1.7), carbamazepine (CBZ; 0.4, 0.1-2.1), caffeine (CAF; 0.5-1.9) PCT (1.3, 0.7-2.7) evident due to large 95 their TMFs. provides first evidence drug bioaccumulation indicates varies among compounds.