Generation of an iPSC line (ZZUNEUi021-A) from a hypertrophic cardiomyopathy patient with TNNT2 mutation

• DOI: 10.1016/j.scr.2021.102622
• Publication Date: 2021-12-11T17:22:53Z
• Authors: Yiming Dong; Xiaowei Li; Wanrong Fu; Xiaoxu Tian; Guangli Guo; Ying Peng; Yafei Zhai; Jiangtao Zhao; Zhongren Ding; Xiaoyan Zhao; Jianzeng Dong
• Keywords: Homeobox protein NANOG; Germ layer; Heterozygote advantage

A 25-years-old hypertrophic cardiomyopathy male patient donated his peripheral blood mononuclear cells (PBMCs) with heterozygote mutation in theTNNT2 gene. We generated induced pluripotent stem cell (iPSC) normal karyotypic and expressing NANOG, Lin28, GDF3 DNMT3. The iPSC line has demonstrated pluripotency by differentiating into three germ layers vitro. ZZUNEUi021-A would serve as an vitro model for loss of TNNT2 function.