Generation of iPS cell line (ICGi040-A) from skin fibroblasts of a patient with ring small supernumerary marker chromosome 4

• DOI: 10.1016/j.scr.2022.102740
• Publication Date: 2022-02-28T16:56:19Z
• Authors: M.M. Gridina; A.R. Nurislamov; J.M. Minina; M.E. Lopatkina; G.V. Drozdov; S.A. Vasilyev; L.I. Minaycheva; E.O. Belyaeva; T.V. Nikitina; A.A. Kashevarova; I.N. Lebedev; T.V. Karamysheva; N.B. Rubtsov; O.L. Serov
• Keywords: Male; 0301 basic medicine; 03 medical and health sciences; QH301-705.5; Induced Pluripotent Stem Cells; Karyotype; Humans; Biology (General); Chromosomes, Human, Pair 4; Fibroblasts; Cell Line; 3. Good health

Human induced pluripotent stem cell (iPSC) line, ICGi040-A, was obtained from skin fibroblasts derived from a male patient with mosaic ring small supernumerary marker chromosome 4 (sSMS(4)) and infertility. ICGi040-A cells have karyotype 47,XY,+r(4) in 97% of cells and express a set of pluripotent markers, as well as are able to differentiate in vitro into derivatives of all three embryonic germ layers.