AD-MSCs and BM-MSCs Ameliorating Effects on The Metabolic and Hepato-renal Abnormalities in Type 1 Diabetic Rats

• DOI: 10.1016/j.sjbs.2021.09.067
• Publication Date: 2021-09-30T18:37:06Z
• Authors: Shady G. El-Sawah; Hanan M. Rashwan; Fayez Althobaiti; Adil Aldhahrani; Eman Fayad; El-Shaimaa Shabana; Ehab I. El-Hallous; Rehab M. Amen
• Keywords: 0303 health sciences; 03 medical and health sciences; Original Article; 3. Good health

Diabetes mellitus (DM) is one of the most serious threats in 21th century throughout human population that needs to be addressed cautiously. Nowadays, stem cell injection considered among promising protocols for DM therapy; owing its marked tissues and organs repair capability. Therefore, our 4 weeks study was undertaken elucidate probable beneficial effects two types adult mesenchymal cells (MSCs) on metabolism disturbance some tissue function defects diabetic rats. Animals were classified into groups; control group, group received a single dose adipose tissue-derived MSCs bone marrow-derived MSCs. Herein, both treated groups markedly reduced hyperglycemia resulting from diabetes induction via lowering serum glucose rising insulin C-peptide levels, compared group. Moreover, increased lipid fractions levels reverted back near normal values as consequence untreated Furthermore, found have hepato-renal protective indicated through decreased liver kidney functions markers Taken together, results highlighted therapeutic benefits alleviating metabolic anomalies complications.