Neuropsychiatric, neuropsychological, and neuroimaging features in isolated REM sleep behavior disorder: The importance of MCI

• DOI: 10.1016/j.sleep.2022.08.018
• Publication Date: 2022-09-03T03:18:17Z
• Authors: Mariacarolina Vacca; Francesca Assogna; Clelia Pellicano; Agostino Chiarava...; Fabio Placidi; Francesca Izzi; Riccardo Camedda; Orazio Schillaci; Gianfranco Spalletta; Caterina Lombardo; Nicola Biagio Mer...; Claudio Liguori
• Keywords: REM Sleep; Cognitive function; Neuroimaging; Psychological; REM Sleep; Neuroimaging; REM Sleep Behavior Disorder; Neuropsychological Tests; 3. Good health; Settore MED/26 - NEUROLOGIA; 03 medical and health sciences; Cognition; 0302 clinical medicine; Psychological; Humans; Cognitive Dysfunction; Cognitive function

Mild cognitive impairment (MCI) is frequently diagnosed in patients with isolated rapid eye movement (REM) sleep behavior disorder (iRBD), although the extent of MCI-associated neuropathology has not yet been quantified. The present study compared the differences in neuropsychiatric, neuropsychological, and neuroimaging markers of neurodegeneration in MCI-iRBD and iRBD patients with normal cognition.Sixty-one patients with iRBD were included in the study: 30 patients were included in the MCI subgroup (RBD-MCI) and 31 in the normal cognition subgroup (RBD-NC). Both groups underwent neuropsychiatric and neuropsychological assessments to evaluate psychopathological symptoms and neuropsychological functions. Brain [18F]FDG PET and 123I-FP-CIT-SPECT were performed to evaluate brain glucose metabolism and nigrostriatal dopaminergic function in convenient subgroups of patients, respectively.Neuropsychological measures generally confirmed overall cognitive decline in patients with iRBD-MCI. Immediate long-term verbal memory and visuospatial functions, as well as attentional-executive impairment were evident in the MCI group compared to the NC group. Neuroimaging results indicated reduced brain glucose uptake in the bilateral posterior cingulate cortex and more evident nigrostriatal deafferentation in the RBD-MCI group. There were no differences in psychopathological symptoms between the two groups.This study confirmed that iRBD patients with MCI had a more impaired cognitive status that those with NC. Moreover, the MCI subgroup presented reduced cerebral glucose consumption in brain areas critical for cognition, and a more severe deafferentation of the nigro-striatal regions, highlighting the importance of identifying iRBD patients with MCI for urgent neuroprotective trials.