High-performance non-enzymatic perovskite sensor for hydrogen peroxide and glucose electrochemical detection

• DOI: 10.1016/j.snb.2017.01.012
• Publication Date: 2017-01-05T14:43:10Z
• Authors: Juan He; Jaka Sunarso; Yinlong Zhu; Yijun Zhong; Jie Miao; Wei Zhou; Zongping Shao
• Keywords: 3104 Condensed Matter Physics; 670; 2208 Electrical and Electronic Engineering; 2504 Electronic; 3105 Instrumentation; 2506 Metals and Alloys; Non-enzymatic; 02 engineering and technology; 540; Hydrogen peroxide; Perovskite; 530; 7. Clean energy; Coatings and Films; Glucose; 2508 Surfaces; Optical and Magnetic Materials; 0210 nano-technology; Biosensor; 2505 Materials Chemistry

Abstract Enzymeless detection of hydrogen peroxide (H 2 O 2 ) and glucose offers a more reliable and accurate detection route given the absence of enzyme that is sensitive to temperature, pH, poisoning chemicals, and humidity. This can be realized using electrochemical sensor device which at present relies upon platinum, gold, or palladium-based nanostructured electrodes. Finding an alternative to such noble metal materials becomes crucial to facilitate large-scale applications of such device. Here, we reported that La 0.6 Sr 0.4 CoO 3-δ (LSC) perovskite oxide can provide comparable performance to these noble metal nanomaterials. LSC provides superior electrooxidation activities (to H 2 O 2 and glucose) over La 0.6 Sr 0.4 Co 0.2 Fe 0.8 O 3-δ (LSCF) and LaNi 0.6 Co 0.4 O 3 (LNC) that translates to good H 2 O 2 or glucose detection performance. We proposed parallel pathways for H 2 O 2 and glucose oxidations on LSC perovskite, which proceeds via Co 3+ /Co 4+ redox couple and via oxygen vacancies formation. Additionally, reduced graphene oxide (RGO) can be added to optimize the detection performance. The best electrode, i.e., LSC + RGO/GCE provides sensitivity of 500 and 330 μA mM −1 cm −2 for H 2 O 2 and glucose, respectively, and limit of detection of 0.05 and 0.063 μM for H 2 O 2 and glucose, respectively (at S/N = 3). Its respective linear ranges are 0.2–3350 μM and 2–3350 μM for H 2 O 2 and glucose, respectively.