A novel 2-(Hydroxymethyl)quinolin-8-ol-based selective and sensitive fluorescence probe for Cd2+ ion in water and living cells

• DOI: 10.1016/j.snb.2017.05.103
• Publication Date: 2017-05-19T04:18:49Z
• Authors: Yanpeng Dai; Kun Yao; Jiaxin Fu; Kun Xue; Li Yang; Kuoxi Xu
• Keywords: Hydroxymethyl

Abstract A novel probe 1a based on hydroxymethylquinolin-8-ol was designed and synthesized. Probe 1a exhibited “turn-on” fluorescence response for Cd2+ ion over other ions in aqueous solutions (almost 100% water). The association constants of probe 1a toward Cd2+ ion were found to be 9.00 × 104 M−1 by Benesi–Hildebrand equation (R2 = 0.9995) and the limit of detection was calculated to be 1.18 × 10−6 M. The mechanism of the complexation of 1a with Cd2+ had been studied by 1H NMR, ESI-MS, FT-IR and X-ray crystal. Furthermore, in studies with living cells, probe 1a was almost no toxicity, cell-membrane-permeable and could be used to monitor Cd2+ ion in living cells.