Hydrogen Sulfide Maintains Mesenchymal Stem Cell Function and Bone Homeostasis via Regulation of Ca2+ Channel Sulfhydration

• DOI: 10.1016/j.stem.2014.03.005
• Publication Date: 2014-04-10T17:15:34Z
• Authors: Yi Liu; Ruili Yang; Xibao Liu; Yu Zhou; Cunye Qu; Takashi Kikuiri; Songlin Wang; Ebrahim Zandi; Junbao Du; Indu S. Ambudkar; Songtao Shi
• Keywords: Homeostasis

Gaseous signaling molecules such as hydrogen sulfide (H2S) are produced endogenously and mediate effects through diverse mechanisms. H2S is one gasotransmitters that regulates multiple pathways in mammalian cells, abnormal metabolism has been linked to defects bone homeostasis. Here, we demonstrate marrow mesenchymal stem cells (BMMSCs) produce order regulate their self-renewal osteogenic differentiation, deficiency results BMMSC differentiation. causes aberrant intracellular Ca(2+) influx because of reduced sulfhydration cysteine residues on TRP channels. This decreased flux downregulates PKC/Erk-mediated Wnt/β-catenin which controls differentiation BMMSCs. Consistently, H2S-deficient mice display an osteoporotic phenotype can be rescued by small release H2S. These BMMSCs restoring levels via nontoxic donors may provide treatments for diseases osteoporosis arise from deficiencies.