A stem cell zoo uncovers intracellular scaling of developmental tempo across mammals

• DOI: 10.1016/j.stem.2023.05.014
• Publication Date: 2023-06-20T15:01:39Z
• Authors: Jorge Lázaro; Maria Costanzo; Marina Sanaki-Mat...; Charles Girardot; Masafumi Hayashi; Katsuhiko Hayashi; Sebastian Diecke; Thomas B. Hildebr...; Giovanna Lazzari; Jun Wu; Stoyan Petkov; Rüdiger Behr; Vikas Trivedi; Mitsuhiro Matsuda; Miki Ebisuya
• Keywords: Developmental Biology

Differential speeds in biochemical reactions have been proposed to be responsible for the differences developmental tempo between mice and humans. However, underlying mechanism controlling species-specific kinetics remains determined. Using vitro differentiation of pluripotent stem cells, we recapitulated segmentation clocks diverse mammalian species varying body weight taxa: marmoset, rabbit, cattle, rhinoceros. Together with mouse human, clock periods six did not scale animal weight, but embryogenesis length. The core gene HES7 displayed clear scaling period. cellular metabolic rates show an evident correlation. Instead, genes involving showed expression pattern that scales Altogether, our cell zoo uncovered general laws governing tempo.