Fractalkine enhances oligodendrocyte regeneration and remyelination in a demyelination mouse model

• DOI: 10.1016/j.stemcr.2022.12.001
• Publication Date: 2023-01-05T16:07:46Z
• Authors: Monique M.A. de A...; Adrianne E.S. Watson; Sana Bibi; Nicole L. Dittmann; Kara Goodkey; Pedram Sharafodin...; Danny Galleguillos; Maryam Nakhaei-Nejad; Jayasankar Kosaraju; Noam Steinberg; Beatrix S. Wang; Tim Footz; Fabrizio Giuliani; Jing Wang; Simonetta Sipione; Julia M. Edgar; Anastassia Voronova
• Keywords: Remyelination

Demyelinating disorders of the central nervous system (CNS) occur when myelin and oligodendrocytes are damaged or lost. Remyelination regeneration can be achieved from endogenous oligodendrocyte precursor cells (OPCs) that reside in adult CNS tissue. Using a cuprizone mouse model demyelination, we show infusion fractalkine (CX3CL1) into demyelinated murine brain increases de novo formation enhances remyelination corpus callosum cortical gray matter. This is by increased OPC proliferation matter as well differentiation attenuation microglia/macrophage activation both Finally, activated OPCs microglia/macrophages express receptor CX3CR1 vivo, OPC-microglia co-cultures vitro modulating microglia biology. Our results demonstrate novel pro-regenerative role demyelinating model.