Optimization of semisolid extrusion (pressure-assisted microsyringe)-based 3D printing process for advanced drug delivery application

• DOI: 10.1016/j.stlm.2021.100008
• Publication Date: 2021-02-23T03:05:55Z
• Authors: Abdul Aleem Mohammed; Mohammed S. Algah...; Mohammad Zaki Ahmad; Javed Ahmad
• Keywords: Optimization; Process parameters; Drug delivery; Medical technology; Pharmaceuticals; 3D printing; 04 agricultural and veterinary sciences; R855-855.5; 0405 other agricultural sciences; Semisolid extrusion (pressure-assisted microsyringe); 3. Good health

3D printing of pharmaceutical formulations requires juggling between the material properties and process to achieve geometry printed products with desired dose release. The purpose current investigation is identify suitability for semisolid extrusion-based advanced drug delivery system. In this study, technique was optimized print a controlled release shell as vehicle/carrier oral consistency printable paste by screening different solvents polymer interest (cellulose acetate optimum) continuous uniform extrudability behavior. polarity solvent played important role in selection suitable optimization process. nozzle shape (tapered tip diameter (630 µm were found be also significantly influenced extrusion pressure (60 psi) speed (4 mm/s) reach required rate during thickness width layers have contributed creation standard triangle language (STL) G-code It that first layer deposited on particular type substrate plays significant influence spreadable behavior extruded materials. Finally, present study design proposes rational guideline specific personalized medicine.