How insulin-like growth factor I binds to a hybrid insulin receptor type 1 insulin-like growth factor receptor

• DOI: 10.1016/j.str.2022.05.007
• Publication Date: 2022-06-03T14:43:42Z
• Authors: Yibin Xu; Mai B. Margetts; Hari Venugopal; John G. Menting; Nicholas S. Kirk; Tristan I. Croll; Carlie Delaine; Briony E. Forbes; Michael C. Lawrence
• Keywords: Insulin receptor substrate; GRB10

Monomers of the insulin receptor and type 1 insulin-like growth factor (IGF-1R) can combine stochastically to form heterodimeric hybrid receptors. These receptors display ligand binding signaling properties that differ from those homodimeric Here, we describe cryoelectron microscopy structure such a in complex with I (IGF-I). The (ca. 3.7 Å resolution) displays single IGF-I ligand, bound similar fashion seen for IGFs IGF-1R. engages first leucine-rich-repeat domain cysteine-rich region IGF-1R monomer (rather than monomer), consistent determinants IGF residing region. broadens our understanding this family assists delineating key structural motifs involved their respective ligands.