Impact of C-reactive protein–albumin–lymphocyte (CALLY) index on prognosis after hepatectomy for colorectal liver metastasis

• DOI: 10.1016/j.suronc.2023.101911
• Publication Date: 2023-02-08T02:54:30Z
• Authors: Kenei Furukawa; Masashi Tsunematsu; Yoshiaki Tanji; Shunta Ishizaki; Munetoshi Akaoka; Koichiro Haruki; Tadashi Uwagawa; Shinji Onda; Michinori Matsumoto; Toru Ikegami
• Keywords: 03 medical and health sciences; C-Reactive Protein; 0302 clinical medicine; Lymphatic Metastasis; Liver Neoplasms; Humans; Hepatectomy; Prognosis; Colorectal Neoplasms; 3. Good health; Retrospective Studies

The C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index is a novel inflammation-based biomarker. We aimed to investigate whether the CALLY can predict the prognosis in patients with colorectal liver metastases (CRLM) after hepatic resection.We included 183 patients with CRLM who underwent hepatectomy. The CALLY index was defined as (albumin × lymphocytes)/(CRP × 104). We investigated the association of the CALLY index with overall survival by univariate and multivariate analyses.In total, 101 (55%) patients had a low CALLY index (<4). In the univariate analysis, overall survival was significantly worse in patients with lymph node metastases (p = 0.02), extrahepatic lesions (p < 0.01), and a low CALLY index (p < 0.01). In the multivariate analysis, independent and significant predictors of overall survival were lymph node metastases (p = 0.04), extrahepatic lesions (p = 0.03), and a low CALLY index (p = 0.03). Patients with a low CALLY index had significantly more postoperative complications than those with a high CALLY index (29% vs. 11%, p < 0.01).The CALLY index may be an independent and significant indicator of outcomes in patients who underwent liver resection for CRLM.