Polyphenolic compounds affect the long-term degradation behaviour of polymer and composite materials based on PCL, PLGA, and bioactive glass

• DOI: 10.1016/j.susmat.2023.e00568
• Publication Date: 2023-01-11T01:30:14Z
• Authors: Michal Dziadek; Kinga Dziadek; Kamila Checinska; Szymon Salagierski; Emilia Choinska; Piotr Szatkowski; Aleksandra Wajda; Aneta Kopec; Katarzyna Cholewa...
• Keywords: PLGA; Bioactive Glass; Degradation; Biodegradable polymer

In recent years, the modification of biodegradable aliphatic polyesters with bioactive ceramics and plant-derived active agents has gained much attention in biomedical applications. They provide significant improvement biological functionality synthetic polymers. However, they simultaneously affect numerous physicochemical properties. this work, for first time, effect incorporation polyphenols (PPh) extracted from sage sol-gel-derived glass (BG) particles, either alone or combination, into poly(ε-caprolactone) (PCL) poly(lactic-co-glycolide) (PLGA) was evaluated. BG particles were shown to accelerate degradation materials based on slowly degrading polymer - PCL, while fast – PLGA retarded. For PLGA-based composites, formation apatite layer dissolution alkaline ions appear have pivotal role controlling by providing protection direct exposition aqueous environment neutralizing acidic by-products. PPh all studied materials. The following PPh-related factors can be involved process: wettability improvement, acid catalysis, plasticizing effect, porosity formation. Our results highlighted importance considering commonly used polymeric modifiers one most important properties biomaterials tissue engineering drug delivery degradation.