Nucleolin: a binding partner of G-quadruplex structures

• DOI: 10.1016/j.tcb.2022.03.003
• Publication Date: 2022-04-08T12:29:15Z
• Authors: Tiago Santos; Gilmar F. Salgado; Eurico J. Cabrita; Carla Cruz
• Keywords: Nucleolin

Nucleolin protein is involved in a plethora of cellular pathways across the nucleolus, nucleus, and cytoplasm. The association of its RNA-binding domain (RBD) and its RGG (arginine-glycine-glycine-rich) domain allows it to interact with G-quadruplex structures in nucleic acids. We highlight evidence that the nucleolin/G-quadruplex partnership is of extensive relevance to neurodegenerative disease, cancer, and viral infections.