The obese brain: is it a matter of time?

2. Zero hunger 0301 basic medicine 03 medical and health sciences
DOI: 10.1016/j.tem.2023.08.003 Publication Date: 2023-08-26T12:11:19Z
ABSTRACT
Understanding how obesity rewires the brain, triggers neuroinflammation and neurodegeneration relies on research using animal models. There is, however, a disconnect between the timeline of human obesity and typical preclinical protocols. We emphasize here the need to adopt models of chronic obesity to study the pathophysiology of human obesity.
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