Syntheses of methylenolactocin and nephrosterinic acid via diastereoselective acylation and chemoselective reduction–lactonization

• DOI: 10.1016/j.tet.2009.06.016
• Publication Date: 2009-06-11T08:46:56Z
• Authors: Rattana Jongkol; Ruangrat Choommon...; Bongkoch Tarnchompoo; Piyarat Nimmanpipug; Puttinan Meepowpan
• Keywords: Chemoselectivity; Tandem

Abstract The syntheses of methylenolactocin, nephrosterinic acid and their derivatives can be achieved by using the efficient diastereoselective acylation of dimethyl itaconate–anthracene adduct followed by tandem chemoselective reduction–lactonization.