Copper-catalyzed dehydrogenative reaction: synthesis of amide from aldehydes and aminopyridine

• DOI: 10.1016/j.tet.2013.05.072
• Publication Date: 2013-05-23T10:45:39Z
• Authors: Sizhuo Yang; Hao Yan; Xiaoyu Ren; Xiaokang Shi; Jian Li; Yuling Wang; Guosheng Huang
• Keywords: Amide; Aminopyridines; 2-Aminopyridine

AbstractA simple protocol using air as the oxidant is developed for the synthesis of benzamides via oxidative amidation of benzaldehydes with aminopyridine derivatives.