New anti-infective cycloheptadepsipeptide congeners and absolute stereochemistry from the deep sea-derived Streptomyces drozdowiczii SCSIO 10141

• DOI: 10.1016/j.tet.2014.02.007
• Publication Date: 2014-02-08T12:30:54Z
• Authors: Xiao Zhou; Hongbo Huang; Jie Li; Yongxiang Song; Renwang Jiang; Jing Liu; Si Zhang; Yan Hua; Jianhua Ju
• Keywords: 14. Life underwater; 01 natural sciences; 0104 chemical sciences

Six cycloheptadepsipeptides, marformycins A-F (1-6), featuring a unique N-terminally formylated side chain and five non-proteinogenic amino acid residues, were isolated from the deep Sea-derived Streptomyces drozdowiczii SCSIO 10141. The previously unsolved absolute stereochemistry of 3 and 4 was determined and the structures of other four new congeners were elucidated by extensive spectroscopic, chiral-phase HPLC, and single-crystal X-ray diffraction analyses. Compounds 1-5 bear no cytotoxicity against a number of human tumor cell lines but show selective anti-infective activity against Micrococcus luteus. (C) 2014 Elsevier Ltd. All rights reserved.