Synthesis and biological evaluation of substituted 2-anilino-7H-pyrrolopyrimidines as PDK1 inhibitors

• DOI: 10.1016/j.tet.2014.05.033
• Publication Date: 2014-05-21T09:16:02Z
• Authors: Nathan J. O'Brien; Martin Brzozowski; David J.D. Wilson; Leslie W. Deady; Belinda M. Abbott
• Keywords: 0301 basic medicine; 03 medical and health sciences; 01 natural sciences; 0104 chemical sciences; 3. Good health

AbstractTitle compounds (V) are synthesized via sequential Suzuki coupling of dichloro‐pyrrolopyrimidine (I) with boronate (II) followed by Buchwald—Hartwig cross‐coupling with various customized anilines (IV).