Atranones with enhancement neurite outgrowth capacities from the crinoid-derived fungus stachybotrys chartarum 952

• DOI: 10.1016/j.tet.2017.11.006
• Publication Date: 2017-11-06T16:32:39Z
• Authors: Yong-Fang Li; Pan-Pan Zhang; Su-Jun Yan; Jia-Yi Xu; Shah-Iram Niaz; Raza Chand; Chi Him Eddie Ma; Yong-Cheng Lin; Jing Li; Lan Liu
• Keywords: Crinoid; Neurite

Abstract Seven new atranones (1–5, 7, 10) and three known analogues (6, 8, 9) were isolated from the marine crinoid-derived toxigenic fungus Stachybotrys chartarum 952. The structures of these compounds were elucidated by spectroscopic analysis as well as X-ray crystallographic analysis and electronic circular dichroism calculations. The absolute configurations of three known compounds 6, 8, 9 were first determined. Compound 8 promoted neurite outgrowth from adult DRG neurons significantly without affecting cell survival at 1 μg/mL concentrations.