An L-tert-leucine derived urea catalyzed asymmetric synthesis of acylclic N, N′-ketals derived from aryl amines and isatin-derived ketimines

• DOI: 10.1016/j.tet.2021.132206
• Publication Date: 2021-05-15T15:11:20Z
• Authors: Shuo Liu; Jingdong Wang; Zhonglin Wei; Jungang Cao; Dapeng Liang; Yingjie Lin; Haifeng Duan
• Keywords: Isatin

Abstract An asymmetric synthesis of N,N′-ketal compounds derived from isatin-derived ketimines and aryl amines has been developed using an inexpensive and readily available L-tert-leucine derived urea catalyst. Using this asymmetric catalytic synthetic method, a series of 3-substituted 3-amino-2-oxoindole derivatives containing an N,N′-ketal motif were obtained in high yields with high enantioselectivities.