Tetrahydro-1,4-epoxynaphthalene-1-carboxylic acid: a chiral resolving agent for the resolution and absolute configuration assignment of 7,7′-disubstituted 1,1′-bi-2-naphthols

• DOI: 10.1016/j.tetasy.2016.09.003
• Publication Date: 2016-09-30T14:23:04Z
• Authors: Kulvadee Dolsophon; Nopporn Ruangsupa...; Jakapun Soponpong; Suttipun Sungsuwan; Samran Prabpai; Palangpon Kongsaeree; Tienthong Thongpa...
• Keywords: Absolute Configuration; Chiral derivatizing agent; Chiral resolution

Abstract Tetrahydro-1,4-epoxynaphthalene-1-carboxylic acid (THENA), was applied as a chiral derivatizing agent to resolve 7,7′-disubstituted 1,1′-bi-2-naphthol derivatives. This process is very efficient and could potentially be used as a preliminary tool to assign the absolute configuration of substituted 1,1′-bi-2-naphthols by means of a simple TLC.