A simple spiroepoxide as methionine aminopeptidase-2 inhibitor: synthetic problems and solutions

• DOI: 10.1016/j.tetlet.2005.07.136
• Publication Date: 2005-08-12T11:38:04Z
• Authors: Vincent Rodeschini; Pierre Van de Weghe; Céline Tarnus; Jacques Eustache
• Keywords: 01 natural sciences; 0104 chemical sciences

Abstract The preparation of a simple 1-oxa-spiro[2.4]heptane derivative is described. Observations made in the course of the synthesis show again that apparently minor structural modifications of the dienic substrate exert a strong influence on the ring-closing metathesis outcome and that the efficient construction of even simple but highly substituted systems by RCM may constitute a synthetic challenge.