Chemically-enabled synthesis of 1,2,3,4-tetrahydroisoquinolin-1-ones

• DOI: 10.1016/j.tetlet.2009.02.157
• Publication Date: 2009-02-26T09:53:40Z
• Authors: Paul S. Humphries; Gayatri Balan; Bruce M. Bechle; Edward L. Conn; Kenneth J. Dirico; Yu Hui; Robert M. Oliver; James A. Southers; Xiaojing Yang
• Keywords: 01 natural sciences; 0104 chemical sciences

We have developed a number of efficient protocols for the facile synthesis of 1,2,3,4-tetrahydroisoquinolin-1-ones. This synthetic methodology allowed concise and efficient exploration of the SAR in all areas of the molecule. A number of these methods proved to be versatile, efficient and amenable to parallel synthesis.