Stereoselective total synthesis of paecilomycin E

• DOI: 10.1016/j.tetlet.2011.10.137
• Publication Date: 2011-11-01T22:36:40Z
• Authors: P. Srihari; B. Mahankali; K. Rajendraprasad
• Keywords: 01 natural sciences; 0104 chemical sciences

First total synthesis of recently isolated resorcylic acid lactone paecilomycin E has been accomplished. The key reactions include olefin metathesis, Mitsunobu reaction, Stille coupling and regioselective allylation.