A new facile synthesis of steroid dimers containing 17,17′-dicarboxamide spacers

• DOI: 10.1016/j.tetlet.2013.02.108
• Publication Date: 2013-03-21T03:16:37Z
• Authors: Rui M.B. Carrilho; Mariette M. Pereira; Maria José S.M. M...; Attila Takács; László Kollár
• Keywords: 01 natural sciences; 0104 chemical sciences; 3. Good health

Abstract A set of new steroid dimers linked through ring D–ring D were synthesized via catalytic diaminocarbonylation of 17-iodo-5α-androst-16-ene, in the presence of palladium–phosphine in situ catalysts and aliphatic or aromatic diamines as N -nucleophiles. The dimeric steroidal compounds containing 17,17′-dicarboxamide spacers were obtained through highly chemoselective reactions in good isolated yields and completely characterized by spectroscopic techniques.