Organocatalytic asymmetric sulfa-Michael addition of thiols to trans-3,3,3-trifluoropropenyl phenyl sulfone

• DOI: 10.1016/j.tetlet.2013.06.059
• Publication Date: 2013-06-20T11:31:02Z
• Authors: Xin Fang; Xiu-Qin Dong; Yuan-Yuan Liu; Chun-Jiang Wang
• Keywords: Stereocenter; Sulfone; Michael reaction; Tertiary amine

AbstractThe first asymmetric sulfa‐Michael addition of thiols to trans‐3,3,3‐trifluoropropenyl phenyl sulfone (I) for the construction of an unique stereogenic center bearing a trifluoromethyl group and a sulfur atom is achieved in high yields and moderate to good enantioselectivities with a chiral bifunctional amine—thiourea catalyst.