Preparation of phenolic compounds through catalyst-free ipso-hydroxylation of arylboronic acids

• DOI: 10.1016/j.tetlet.2014.02.048
• Publication Date: 2014-02-22T05:15:41Z
• Authors: Mukut Gohain; Maretha du Plessis; Johannes H. van T...; Barend C.B. Bezui...
• Keywords: Hydroxylation

A novel method for the preparation of phenolic compounds through ipso-hydroxylation of the corresponding widely available arylboronic acid precursors is described. Through application of a novel PEG400-H2O2 reactant system, a variety of substituted phenols and other aromatic analogues have been prepared in excellent yields at room temperature in the absence of any catalyst.