Ligand-free copper(0) catalyzed direct C–H arylation of 1,2,4-triazoles and 1,3,4-oxadiazoles with aryl iodides in PEG-400

• DOI: 10.1016/j.tetlet.2014.12.064
• Publication Date: 2014-12-16T17:52:31Z
• Authors: Ramu Tadikonda; Mangarao Nakka; Srinuvasarao Raya...; Siva Prasada Kuma...; Siddaiah Vidavalur
• Keywords: 01 natural sciences; 0104 chemical sciences

Abstract A ligand-free copper catalyzed approach has been developed to the synthesis of 3,4,5-triaryl-1,2,4-triazoles and 2,5-diaryl-1,3,4-oxadiazoles by the direct arylation of corresponding 3,4-diaryl-1,2,4-triazoles and 2-aryl-1,3,4-oxadiazoles with aryl iodides using PEG-400 as reaction medium. The procedure is experimentally simple and free from addition of external chelating ligands or co-catalysts.