Pot, atom and step economic (PASE) synthesis of 5-monoalkylbarbiturates through domino aldol-Michael reaction

• DOI: 10.1016/j.tetlet.2014.12.091
• Publication Date: 2014-12-24T05:15:47Z
• Authors: Subarna Jyoti Kalita; Hormi Mecadon; Dibakar Chandra Deka
• Keywords: Domino; Aldol reaction; Cascade reaction; Michael reaction; One-pot synthesis; Simplicity; Atom economy; Reaction conditions

A simple pot, atom and step economic (PASE) approach for the synthesis of 5-monoalkylbarbiturates by a one-pot reaction of barbituric acids, aldehydes, and ketones, involving a domino aldol-Michael reaction is described. The operational simplicity and cost effectiveness of this procedure makes it a sustainable strategy for the synthesis of 5-monoalkylbarbiturates.