New thioureas based on thiazolidines with antioxidant potential

• DOI: 10.1016/j.tetlet.2015.10.037
• Publication Date: 2015-10-25T07:30:42Z
• Authors: Tiago Lima da Silva; Laura Maria Forai...; Fernanda S.S. Sousa; Lucimar M.P. Brod; Lucielli Savegnago; Paulo Henrique Sc...
• Keywords: 01 natural sciences; 0104 chemical sciences; 3. Good health

Abstract Thiazolidine and pyrrolidine compounds containing a thiourea moiety were prepared using boric acid as a coupling agent in a multicomponent methodology. In addition, the antioxidant activity, as reflected by free radical scavenging, was evaluated. Some compounds were selected and tested in different antioxidant experiments and all of them were shown to be useful for the prevention of oxidative stress in biological systems and thus capable of reducing cellular injury.