Nickel-mediated C(sp2)-H amidation in synthesis of secondary sulfonamides via sulfonyl azides as amino source

• DOI: 10.1016/j.tetlet.2021.152825
• Publication Date: 2021-01-23T09:07:39Z
• Authors: Peng Xu; Peng-Fei Ding; Mei-Qi Zhang; Yu-Shi Xia; Ting Xie
• Keywords: 01 natural sciences; 0104 chemical sciences

Abstract In this paper, Ni(II)- Catalyzed ortho-amidation of C(sp2)-H bond with sulfonyl azides directed by (quinolin-8-yl) amine (AQ-amine) is described. The method provides a straightforward method for the synthesis of sulfonamides from available sulfonyl azides via the transition-metal-catalyzed C(sp2)-N bond forming reaction. The amidation reactions exhibit high functional group compatibility, which might proceed a Ni(III)/Ni(I) catalytic cycle. We also applied sulfonamide compound in OLEDs, which exhibits the certain application potential in OLEDs field.