Design, synthesis and cytotoxic evaluation of diphenyl(quinolin-8-yl)phosphine oxides

• DOI: 10.1016/j.tetlet.2021.153019
• Publication Date: 2021-03-23T20:38:27Z
• Authors: Asier Selas; Guillermo Ramírez; Francisco Palacios; Concepción Alonso
• Keywords: Aldimine

A new strategy is reported for the synthesis of quinolinylphosphine oxides via Povarov reaction between phosphorous aldimines and acetylenes. Moreover, these compounds were studied in vitro cytotoxicity on a human lung alveolus adenocarcinoma (A 549) cell line, demonstrating strong inhibition growth.