Importance of local glycan heterogeneity for in vivo cancer targeting

• DOI: 10.1016/j.tetlet.2021.153089
• Publication Date: 2021-04-19T03:29:36Z
• Authors: Ivan Smirnov; Igor Nasibullin; Almira Kurbangalieva; Katsunori Tanaka
• Keywords: 0301 basic medicine; Targeting; 03 medical and health sciences; 6π-Azaelectrocyclization; Albumin; N-glycan; 500; 540; RIKEN click reaction; 3. Good health

Abstract The preparation of heterogeneous glycoclusters on human serum albumin, containing two structurally non-identical N-glycans, is reported. In agreement with the cell-based interaction data, the trivial structural difference in local glycan heterogeneity can affect the in vivo distribution and cancer accumulation.