Risk of venous thromboembolism and major bleeding in the clinical course of osteosarcoma and Ewing sarcoma

• DOI: 10.1016/j.thromres.2022.11.007
• Publication Date: 2022-11-18T07:26:00Z
• Authors: Fleur H.J. Kaptein; Milou A.M. Stals; Richard E. Evenhuis; Hans Gelderblom; Menno V. Huisman; Diederik S.A. Karis; Renee W.D. Noten; Suzanne C. Canneg...; Frank M. Speetjens; Arjan J. Verschoor; Henri H. Versteeg; Michiel A.J. van ...; Frederikus A. Klok
• Keywords: Cumulative incidence

Patients with osteosarcoma (OS) and Ewing sarcoma (ES) are considered to have a high venous thromboembolism (VTE) risk, although the exact incidence prognostic impact under-researched in general as well relevant age groups.To study of VTE major bleeding (MB) OS ES patients, subdivided children, Adolescents Young Adults (AYAs; aged 18-39) older adults.Retrospective single-center chart review 519 165 patients treated between 1980 2018. were followed from diagnosis until an outcome interest (VTE, MB) or death occurred. Cumulative incidences estimated competing risk. Cox models used determine impact.Five-year cumulative 12 % (95%CI 9.1-15) for 6.7 3.5-11) mostly happening ≥18 years; most frequent presentation was catheter-related upper-extremity thrombosis (OS: 18/65, ES: 7/11). Five-year MB 5.8 4.0-8.1) 5.4 2.5-9.8) patients. 192 77 AYAs included, who faced similar adults. In OS, both associated mortality (adjusted HRs 2.0 [95%CI 1.4-2.9] 2.4 1.4-4.0], respectively), whereas this association only present (aHR 3.4 1.2-9.6]).VTE is complication adult lesser extent while rate comparably types.