Does chromatin function as a metabolite reservoir?

• DOI: 10.1016/j.tibs.2022.03.016
• Publication Date: 2022-04-11T04:08:35Z
• Authors: Vinícius D. Nirello; Dieggo Rodrigues ...; Nathália V.P. Araújo; Patrick D. Varga-...
• Keywords: Histones; 0303 health sciences; 03 medical and health sciences; Acylation; Acyl Coenzyme A; Protein Processing, Post-Translational; Chromatin

Alternative histone acylations integrate gene expression with cellular metabolic states. Recent measurements of cellular acyl-coenzyme A (acyl-CoA) pools highlight the potential that histone post-translational modifications (PTMs) contribute directly to the regulation of metabolite pools. A metabolite-centric view throws new light onto roles and evolution of histone PTMs.