CDCA3 exhibits a role in promoting the progression of ovarian cancer

• DOI: 10.1016/j.tice.2022.101903
• Publication Date: 2022-08-24T04:17:50Z
• Authors: Shan Gong; Bo Bai; Guangyu Sun; Haihong Jin; Zhengmao Zhang
• Keywords: Ovarian Neoplasms; 0301 basic medicine; Apoptosis; Cell Cycle Proteins; Carcinoma, Ovarian Epithelial; 3. Good health; Gene Expression Regulation, Neoplastic; 03 medical and health sciences; Cell Line, Tumor; Humans; Female; Cisplatin; Cell Proliferation

Ovarian cancer (OC) is one of the common gynecological malignant tumors. Cell division cycle-associated protein-3 (CDCA3) involved in regulation cell cycle progression. The role CDCA3 OC was explored this study.The expression evaluated Gene Expression Omnibus (GEO) database and further verified by qRT-PCR Western blot (WB). Subsequently, we established lentivirus-mediated knockdown lines HO-8910 A2780. biological roles on proliferation, sensitivity to cisplatin, apoptosis, migration tumor formation were investigated using loss-of-function assays.CDCA3 frequently up-regulated OC. Knockdown CDAC3 inhibited proliferation migration, enhanced apoptosis as well cells cisplatin. In vivo results confirmed inhibitory effect growth.Our findings indicated that may play an important progression, serve a potential therapeutic target for treatment.