The 'middle-aging' brain

• DOI: 10.1016/j.tins.2024.02.001
• Publication Date: 2024-03-19T14:32:09Z
• Authors: Sebastian Dohm-Ha...; Jane A. English; Aonghus Lavelle; Carlos P. Fitzsimons; Paul J. Lucassen; Yvonne M. Nolan

Middle age has historically been an understudied period of life compared to older age, when cognitive and brain health decline are most pronounced, but the scope for intervention may be limited. However, recent research suggests that middle could mark a shift in aging. We review emerging evidence on multiple levels analysis indicating midlife is defined by unique central peripheral processes shape future trajectories health. Informed developments aging lifespan studies humans animal models, we highlight utility modeling non-linear changes study samples with wide subject ranges distinguish stage-specific from those acting linearly throughout lifespan.