Serum neprilysin levels are elevated in preeclampsia

• DOI: 10.1016/j.tjog.2021.07.015
• Publication Date: 2021-09-07T06:31:13Z
• Authors: Nevin Tüten; Eduard Malik; Koray Gök; Kübra Hamzaoglu; Melike Makul; Yahya Özgün Öner; Huri Bulut; Abdullah Tüten; Onur Güralp
• Keywords: System; Expression; Blood Pressure; Gestational Age; Heart-Failure; Young Adult; 03 medical and health sciences; 0302 clinical medicine; Pre-Eclampsia; Pregnancy; Villi; Humans; Natriuretic peptides; Natriuretic Peptides; Enkephalinase; Endopeptidase; Inhibition; Hydrolysis; Gynecology and obstetrics; Neutral endopeptidase; Neutral Endopeptidase; 3. Good health; Human Placenta; Soluble Neprilysin; Case-Control Studies; Blood pressure; RG1-991; Female; Neprilysin; Biomarkers

To evaluate the possible associations between serum Neprilysin (NEP) levels and preeclampsia and mild and severe preeclampsia subgroups.Fifty-five consecutive women with mild preeclampsia and fifty-five consecutive women with severe preeclampsia were compared with 110 approximately gestational age-matched (±1 week) women with an uncomplicated pregnancy.Mean serum NEP was significantly higher in women with preeclampsia compared to that of the gestational age-matched-controls (231.62 ± 65.30 pg/mL vs. 187.75 ± 84.38 pg/mL, p < 0.001). Mean serum NEP was significantly higher in the mild preeclampsia group compared to its gestational age-matched control group (228.84 ± 67.26 pg/mL vs. 186.14 ± 85.09 pg/mL, p = 0.008); and in the severe preeclampsia group compared to its gestational age-matched control group (234.45 ± 63.85 pg/mL vs. 189.29 ± 84.59 pg/mL, p = 0.004). Serum NEP was positively correlated with systolic and diastolic blood pressure, BUN, uric acid, and creatinine.Mean serum NEP was significantly higher in women with preeclampsia than women with an uncomplicated pregnancy. Further studies are needed to elucidate the possible therapeutic role of NEP inhibitors to treat preeclampsia.