Neonatal chlorpyrifos exposure induces loss of dopaminergic neurons in young adult rats

• DOI: 10.1016/j.tox.2015.07.014
• Publication Date: 2015-07-26T14:13:47Z
• Authors: Jie Zhang; Hongmei Dai; Yuanying Deng; Jing Tian; Chen Zhang; Zhiping Hu; Guoying Bing; Lingling Zhao
• Keywords: Neurotoxicity; Dopaminergic pathways

Increasing epidemiological and toxicological evidence suggests that pesticides other environmental exposures may be associated with the development of Parkinson's disease (PD). Chlorpyrifos (CPF) is a widely used organophosphorous pesticide developmental neurotoxicity. Its neurotoxicity, notably on monoamine system, exposure CPF induce dopaminergic neuronal injury. We investigated whether neonatal to contributes initiation progression neurotoxicity explored possible underlying mechanisms. The newborn rats were administrated 5 mg/kg subcutaneously from postnatal day (PND) 11 PND 14 daily. effect neurons, microglia, astrocyte, nuclear factor-κB (NF-κB) p. 65 38 mitogen-activated protein kinase (MAPK) signaling pathways was analyzed in substantia nigra at 12h, 24h, 72 h, 16d 46 d after exposure. CPF-treated exhibited significant reduction neurons exposure, increase expression microglia astrocytes Intense activation NF-κB MAPK inflammatory observed. Our findings indicate long-term damage mediated by response via nigrostriatal system.