Assessment of the effect of sub-lethal acute toxicity of Emamectin benzoate in Labeo rohita using multiple biomarker approach

• DOI: 10.1016/j.toxrep.2022.01.001
• Publication Date: 2022-01-05T17:25:17Z
• Authors: Vikas Kumar; Himanshu Sekhar S...; Basanta Kumar Das; Sankhajit Roy; Aurobinda Upadhyay; Mitesh Hiradas Ra...; Ramen Kumar Kole; Hemanta Banerjee
• Keywords: Transaminase

Emamectin benzoate (EMB) is a potent neurotoxin agent, widely used for ectoparasites control in aquaculture, but their detailed toxicological implications Labeo rohita are unknown. Thus, this study was conceptualized to determine the LC50 and investigate effects of two sub-lethal concentrations 1/50th 96 h (1.82 μgL-1) 1/10thof (9.1 on hemato-immunological biochemical responses L. (mean weight 25.54 ± 2.3 g length 10.35 2.4 cm) period 24 h, 48 72 h. EMB were 163 μgL-1, 112 99 μgL-1 91 at respectively. The safe limit 2.30 μgL-1. In treated fish, red blood cells, white hemoglobin, hematocrit counts reduced (p < 0.05) significantly. Superoxide dismutase (SOD) activity liver kidney declined while gill muscle increased Glutathione-s-transferase (GST) liver, gill, decreased Catalase (CAT) increases. Glutamic-oxaloacetic acid transaminase (GOT) Glutamate pyruvate (GPT) kidney, tissue. change serum triglycerides, protein level noticed. cortisol, heat shock 70 (HSP70), HSP90 immunological like immunoglobulin M (IgM) complement 3(C3) exposed fish. exposure induces several hemato-immuno, alterations blood, serum, different organs. overall result present indicated that toxic fish even short-term low doses, therefore utmost caution should be taken prevent drainage into water bodies.