Mitigation of apoptosis-mediated neurotoxicity induced by silver nanoparticles via rutaceae nutraceuticals: P53 activation and Bax/Bcl-2 regulation

• DOI: 10.1016/j.toxrep.2022.11.009
• Publication Date: 2022-11-29T08:08:44Z
• Authors: Rehab M. Abdel-Me...; Sanaa A. Ali; Wagdy B. Khalil; Esraa A. Refaat; Mai O. Kadry
• Keywords: Neurotoxicity; Nutraceutical

Rapid progress in nano-scales and nanostructure extremely altered the way of diagnosing or preventing numerous diseases. One most important nano-medicines used cancer treatment diagnosis is silver nanoparticles (AgNPs). Regardless their extensive utilization, prospective neurotoxicity wasn't studied yet. Herein, male Swiss Albino mice were intoxicated via two Nano-scales AgNPs; (20 nm 100 nm) for one month (100 mg/kg) then treated by leaves extracts both